Long-acting HIV Pre-exposure Prophylaxis (PrEP) Approaches: Recent advances, emerging technologies, and development challenges
This review from Expert Opinion on Drug Delivery discusses the current state of the long acting PrEP field, recent advances, and emerging technologies, including ARV prodrug modifications and new drug delivery systems. Technological challenges, knowledge gaps, preclinical testing considerations, and future directions important in the context of clinical translation and implementation of long acting HIV PrEP are discussed.
Costs and Cost-Effectiveness of Biomedical, Non-Surgical HIV Prevention Interventions: A systematic literature review
This article from PharmacoEconomics synthesizes findings on cost and cost-effectivness of different biomedical HIV prevention options and identifies remaining knowledge gaps to suggest future research priorities.
HIV Prevention for the Next Decade: Appropriate, person-centred, prioritised, effective, combination prevention
In light of the development of new HIV prevention technologies, this article from PLOS Medicine proposes a new approach to HIV prevention, that emphasises appropriate, person-centred, prioritised, effective, combination HIV prevention within a framework that reduces existing barriers to services and acknowledges heterogeneity, autonomy, and choice.
End-user Research in Support of Long-acting Systemic Antiretroviral Delivery Systems: Insights from qualitative research with providers and target users in South Africa
This article from BMC Infectious Diseases describes qualitative research investigating perceptions of and preferences for a long-acting, biodegradable implantable PrEP product designed to address challenges relating to adhering to a daily pill regimen amongst adolescent girls and young women and sex workers in Guateng Province, South Africa.
Daily Oral PrEP, Event-Driven PrEP, PrEP Ring, and CAB PrEP Template Guidelines
The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) pre-exposure prophylaxis (PrEP) recommendations and guidance, including those for tenofovir disoproxil fumarate (TDF)-based daily and event-driven oral PrEP, the monthly dapivirine vaginal ring (“PrEP ring” or “the ring”), and…
A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection
This article from JAIDS describes the results of a randomized, double-blind, placebo-controlled, phase 1 trial of a next-generation radiopaque islatravir-eluting implant to assess safety, tolerability, and pharmacokinetics.
Potential of Long-Acting Products to Transform the Treatment and Prevention of Human Immunodeficiency Virus (HIV) in Infants, Children, and Adolescents
This article from Clinical Infectious Diseases examines the potential of injectable PrEP for HIV prevention in infants, children, and adolescents.
Barriers to Uptake of Long-Acting Antiretroviral Products for Treatment and Prevention of HIV in Low- and Middle-Income Countries
This article from Clinical Infectious Diseases examines potential barriers to scale-up of injectable PrEP in low and middle income countries.
A Qualitative Exploration of New and Existing HIV PrEP Modalities Among Men Who Have Sex with Men in Philadelphia
This article from Open Forum Infectious Diseases explores the treatment characteristics that may influence the willingness and uptake of long-acting injectable PrEP as opposed to the daily pills among a racially diverse sample of gay and bisexual men who have sex with men in Philadelphia, Pennsylvania, USA.
Transgender Women in HPTN 083: An evaluation of safety, efficacy, and gender affirming hormonal therapy interactions with long-acting cabotegravir
This poster from AIDS 2022 presents an analysis of results from the HPTN 083 study, looking at the impact of feminizing gender affirming hormones on cabotegravir (CAB) for PrEP pharmacokinetics.
Results from a Safety Study of the Dapivirine Vaginal Ring and Oral PrEP in Breastfeeding Mother-Infant Pairs
This poster from AIDS 2022 presents results from the MTN-043/B-Protected trial, comparing the safety profile of the dapivirine vaginal ring against oral PrEP use during breastfeeding.