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This report presents the achievements and challenges of the countries regarding the prevention of HIV infection, highlighting the progress that has been made towards the goals set by the governments of the region to end AIDS in the next years. This new edition continues the successful series of in-depth analyzes on HIV infection in Latin America and the Caribbean that began in 2012 with Antiretroviral treatment under the magnifying glass It addresses the different aspects of the response to HIV infection from a public health perspective and provides information to guide governments and partners in improving their initiatives.