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PrEP-it 2.1 released: A new version of PrEP-it is now live at! The major changes include: (1) replacing PrEP_CURR with PrEP_CT (2) incorporating reinitiations into target-setting, using either user-entered data on reinitiations or default reinitiation rates (3) ability to constrain coverage-based targets by budget (4) Better integration of AGYW prioritization module with target-setting and impact (5) faster calculations, and (6) more informative error messages. The built-in help documentation is in the process of being updated to reflect the changes, but the revised tool can be accessed now. If you have previously used the online version of PrEP-it, please note that your saved sessions and templates may not work in the new version and may need to be recreated.

Governments, donors, and other stakeholders in countries at the forefront of oral pre-exposure prophylaxis (PrEP) delivery have encountered several programmatic challenges such as difficulty in setting targets, forecasting commodity needs, and estimating program costs and impact.

In response, the US President’s Plan for Emergency AIDS Relief (PEPFAR) has developed a tool called PrEP-it for PrEP implementation planning, monitoring and evaluation. Key features of PrEP-it include setting national and subnational targets, estimating costs and impact associated with targets, monitoring PrEP initiation, and forecasting drug supply needs.

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PrEP-it is available as a web-based tool (version 2.0) and as an Excel spreadsheet (version 1.0). The web-version is easier to use and recommended for most users. Version 2.0 requires no skill in Microsoft Excel while version 1.0 does require intermediate to high skill in Excel.

Both versions set targets and disaggregate by sublocation, track initiation cascade of PrEP delivery, estimate costs and impact associated with targets, identify priority areas for PrEP for adolescent girls and young women, drug forecasting.

The web version (2.0) includes multiple PrEP methods (e.g., pill, ring, CAB-LA). The Excel version (1.0) examines program capacity for PrEP delivery, offers detailed costing options, and calculates continuation rates from client visit data.

Version 2.0 has a helpful user-guide embedded (instructional videos coming soon). Help for version 1.0 may be found here: PrEP-it 1.0 user guide; PrEP-it 1.0 user guide addendum; FAQs; instructional videos.


Target Setting Guide

This guide accompanies the PrEP-it tool’s target-setting module and provides country teams with a process for contextualizing, drafting, and organizing their targets for PrEP. It outlines some of the considerations involved in this process and provides additional resources to help users make the required decisions on tool inputs and assumptions.

White Paper

This paper describes the development of PrEP-it, lessons learned during development, and the application of PrEP-it for target-setting in Eswatini and Zimbabwe and drug supply management in Ghana and Vietnam.

Have questions about the PrEP-it tool? Email PrEPitHelp-at-AvenirHealth-dot-org

The US Agency for International Development (USAID) funded the development of PrEP-it through the following initiatives: Optimizing Prevention Technology Introduction on Schedule (OPTIONS) Consortium, Health Policy Plus (HP+), the Efficiency and Accountability Technical Assistance to Partners II (EATAP-II), Maximizing Options to Advance Informed Choice for HIV Prevention (MOSAIC), and Preparing for Ring Opportunities through Market Introduction Support and Knowledge Exchange (PROMISE collaboration). This paper describes the development of PrEP-it, lessons learned during development, and the application of PrEP-it for target-setting in Eswatini and Zimbabwe and antiretroviral drug supply forecasting in Ghana and Vietnam.