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In collaboration with the Ministry of Health and National AIDS Council of the Government of the Republic of Zambia, MOSAIC convened the country’s first Activation Session for Youth-focused HIV Prevention Programming in Lusaka in July 2022. The session focused on challenges and potential solutions for interventions engaging adolescent girls and young women and their parents and caregivers on HIV prevention and other sensitive issues, including sexual and reproductive health. This report summarizes consultation proceedings; details examples of innovative approaches to address pervasive youth-parent engagement challenges by national and regional programs; and provides co-created recommendations with practical examples.