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The PrEPWatch Resource Database offers a wide range of material on the status of PrEP as an option for biomedical HIV prevention around the world. Search this database to find step-by-step guidance for rolling out PrEP, summaries of the research to date on safety, efficacy and implementation, tools to assist planning and roll out, country updates on PrEP policy and access, and lessons learned from those efforts.

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7 July 2022

DISCOVER study for HIV pre-exposure prophylaxis (PrEP): F/TAF has a more rapid onset and longer sustained duration of HIV protection compared with F/TDF

In the DISCOVER study, F/TAF oral PrEP (Descovy) was statistically noninferior to F/TDF oral PrEP (Truvada). However, there were numerically 53% fewer HIV infections in the F/TAF arm vs. F/TDF . This study explores HIV risk, STIs, adherence, and pharmacokinetic data to evaluate this imbalance.

Research

External Link
7 July 2022

DISCOVER Trial Factsheet

This factsheet provides details on the DISCOVER trial to assess whether F/TAF (trade name Descovy) is as safe and effective as an oral daily HIV pre-exposure prophylaxis (PrEP) product.

Community/Advocacy, Research

External Link
7 July 2022

Dapivirine vaginal ring for HIV prevention: modelling health outcomes, drug resistance and cost-effectiveness

A vaginal ring containing dapivirine is effective for HIV prevention as pre-exposure prophylaxis (PrEP). The authors of this article evaluated the potential epidemiological impact and cost-effectiveness of dapivirine vaginal ring PrEP among 22- to 45-year-old women in KwaZulu-Natal, South Africa.

Research, Service Delivery

External Link
7 July 2022

Adoption of guidelines on and use of oral pre-exposure prophylaxis: a global summary and forecasting study

Widespread adoption of WHO PrEP recommendations coincided with a global increase in PrEP use. Although the 2020 global PrEP target will be missed, strong future growth in PrEP use is possible. New PrEP products could expand the PrEP user base, and, with greater expansion of oral PrEP, further adoption of WHO PrEP recommendations, and simplified…

Normative Guidance/Policies, Research, Service Delivery

External Link
7 July 2022

Health system adaptations and considerations to facilitate optimal oral pre-exposure prophylaxis scale-up in sub-Saharan Africa

Countries in sub-Saharan Africa have progressively scaled up oral PrEP as part of combination HIV prevention. Initial scale-up efforts have generated progress, drawing lessons from existing HIV interventions, such as antiretroviral therapy and biomedical prevention. However, beset by unprepared health systems, scale-up has been slow. This review synthesises literature on essential considerations for PrEP scale-up,…

Normative Guidance/Policies, Research, Service Delivery

External Link
7 July 2022

Barriers to Provision HIV Biomedical Prevention Services in sub-Saharan Africa

AVAC conducted a desk review of the HIV prevention policy landscape in eight countries in sub-Saharan Africa. This analysis includes: training requirements for provision of PrEP and contraceptives; clinical guidelines; National Strategic Plans for HIV and Sexual and Reproductive Health; implementation strategies; national policies on age of consent and the criminality of same-sex relationships; in-depth…

Research, Normative Guidance/Policies

External Link
7 July 2022

Developing and Introducing a Dual Prevention Pill- Oral PrEP & oral contraception for HIV and pregnancy prevention

A coalition of partners is developing a novel Dual Prevention Pill (DPP) for prevention of pregnancy and HIV acquisition in high-need countries. In East and Southern Africa — where the DPP is initially planned for introduction — 65 percent of new HIV infections are amongst women aged 15 and over, and 16 percent of women…

Community/Advocacy, Research

Document
7 July 2022

CHARISMA Mobile: Developing a Digital Resource for Empowerment Counseling, Community Health clinic model for Agency in Relationships and Safer Microbicide Adherence

CHARISMA is a PEPFAR- and USAID-funded empowerment counseling intervention designed to help women use oral pre-exposure prophylaxis and other antiretroviral-based HIV prevention technologies safely and effectively by addressing dynamics of their relationships with male partners, including exposure to intimate partner violence. The intervention, designed to be delivered by lay counselors, is being adapted into a…

Research, Service Delivery

Document
7 July 2022

PrEP-it

Stakeholders at the forefront of oral PrEP delivery have encountered several programmatic challenges such as difficulty in setting targets, tracking the continuum of PrEP delivery, and estimating program costs and impact. In response, PEPFA) has developed a Microsoft Excel-based tool called PrEP-it for oral PrEP implementation planning, monitoring and evaluation.

Research, Monitoring & Evaluation, Service Delivery

External Link
1 April 2022

Guidelines for PrEP Ring Pilot Implementation Studies

The intent of this document is to provide adaptable guidelines for the design of Dapivirine ring pilot implementation or post-introduction operations studies to help shape national ring guidelines.

Research, Service Delivery

Document